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Bloom the gelatin: Pour the water into a small bowl and sprinkle the gelatin evenly on top. Set aside.
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Whisk the heavy cream, milk, sugar, vanilla extract and rum together in a saucepan. Slice the vanilla bean in half and scrape the seeds out into the pot with a sharp knife or your thumbnail. Toss the scraped pod into the heavy cream mixture too.
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Bring the mixture to a boil over medium-high heat and then remove the pan from the heat and immediately add the bloomed gelatin. Whisk until the gelatin dissolves into the mixture.
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Pour the mixture into ramekins or molds, dividing it evenly, and refrigerate. Chill for at least 6 hours.
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To make the Blackberry Sauce: Place the sugar, brandy, lemon juice and 3 cups of the blackberries in a medium saucepan. Bring it all to a boil, then lower the heat and simmer for 5 minutes.
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Transfer the blackberries to a food processor and process until smooth. Pour the sauce through a fine mesh strainer to remove the seeds and pulp. Push the sauce through the strainer with the back of a small spoon to extract as much as possible. Add the remaining half a cup of blackberries to the strained sauce. (If the blackberries are large, chop them into 2 or 3 pieces.) Refrigerate the sauce until you are ready to serve.
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To serve fill a bowl bigger than the ramekins with boiling water. Dip the bottom and sides of the ramekins into the water for just 5 seconds. (Do not submerge the ramekins in the water.) Invert each panna cotta onto a small serving plate and gently lift the ramekins to unmold the desserts.
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Spoon some of the sauce onto the plate and on top of the panna cotta, garnish with mint leaves and serve immediately.